Biological Roles of Peptidases in Trypanosomatids
Alane Beatriz Vermelho*, Marta Helena Branquinha1, Claudia M. D’Ávila-Levy2, André Luis Souza dos Santos1, Edilma Paraguai de Souza Dias1, Ana Cristina Nogueira de Melo1
Identifiers and Pagination:Year: 2010
First Page: 5
Last Page: 23
Publisher Id: TOPARAJ-4-5
Article History:Received Date: 26/11/2009
Revision Received Date: 10/2/2010
Acceptance Date: 15/2/2010
Electronic publication date: 18/3/2010
Collection year: 2010
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In this review, we report the recent developments in the characterization of peptidases and their possible biological functions in the Trypanosomatidae family. The focus will be on peptidases from Trypanosoma cruzi, Leishmania spp., African trypanosomes and plant and insect trypanosomatids. There are numerous events in parasite development where the involvement of peptidases has been established, and they will be approached in the present review. Also in this review we will discuss the central roles have been proposed for peptidases in diverse processes such as virulence, host cell interaction and invasion, catabolism of host proteins, differentiation, cell cycle progression and both stimulation and evasion of host immune responses.