Ecto-Nucleoside Triphosphate Diphosphohydrolase Activities in Trypanosomatids: Possible Roles in Infection, Virulence and Purine Recycling
José Roberto Meyer-Fernandes*, 1, Daniela Cosentino-Gomes1, Danielle Pereira Vieira2, Angela Hampshire Lopes2
Identifiers and Pagination:Year: 2010
First Page: 116
Last Page: 119
Publisher Id: TOPARAJ-4-116
Article History:Received Date: 10/11/2009
Revision Received Date: 27/8/2010
Acceptance Date: 28/8/2010
Electronic publication date: 10/12/2010
Collection year: 2010
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Ecto-nucleoside triphosphate diphosphohydrolases (ecto-NTPDases), also known as ecto-ATPases and/or ectoapyrases, are integral membrane glycoproteins or soluble enzymes that are dependent on divalent cations. These ectoenzymes are important ecto-nucleotidases that are characterized by the ability to hydrolyze nucleoside triphosphates and nucleoside diphosphates to the monophosphate form. The hydrolysis of nucleoside monophosphates to nucleosides such as adenosine may then be catalyzed by the action of ecto-5´nucleotidases. The present study reviews the sequential hydrolysis of ATP → ADP → AMP → adenosine catalyzed by these ecto-enzymes from different trypanosomatids. These reactions participate in the salvage of purines in these parasites and simultaneously interfere with the establishment of infection and changes in the host immune response.