Intracellular Signaling Pathways Involved in Cell Differentiation in Trypanosomatids
Angela H. Lopes*, 1, Marta T. Gomes2, Fernando L. Dutra1, Alane B. Vermelho1, José R. Meyer-Fernandes , Mário A. C. Silva-Neto2, Thaïs Souto-Padrón1, Danielle P. Vieira1
Identifiers and Pagination:Year: 2010
First Page: 102
Last Page: 110
Publisher Id: TOPARAJ-4-102
Article History:Received Date: 15/11/2009
Revision Received Date: 19/9/2010
Acceptance Date: 23/9/2010
Electronic publication date: 10/12/2010
Collection year: 2010
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Knowledge of cell signaling pathways in trypanosomatids is crucial for the future design of new drugs to treat diseases caused by these parasites. The publication of the complete genome sequences of three pathogenic trypanosomatids, Trypanosoma brucei, T. cruzi and Leishmania major, revealed numerous protein members of signaling pathways that modulate important processes, such as cell differentiation. Even so, little is known about the role that these proteins play in the physiology of trypanosomatids. This review aims to stimulate discussion on this subject to encourage further studies of the signaling pathways involved in the cell differentiation of trypanosomatids.