RESEARCH ARTICLE


Effectiveness of the Combination of Imidacloprid/ Moxidectin/ Praziquantel and Moxidectin/ Praziquantel Applied Topically in Dogs with Endoparasites and Ectoparasites



Camilo R. Núñez1, Roger I. Rodríguez-Vivas2, Ariadna F. Ortega3, *, Rafael H. Cárdenas4
1 DERMAVET. Veterinary Hospital, José de La Luz Blanco Mz. 187-Lt.33, Iztapalapa, 09510 CDMX, Mexico City, Mexico
2 Campus of Biological and Agricultural Sciences, FMVZ, Autonomous University of Yucatan, km. 15.5 Merida highway -Xmatkuil, Merida, Yucatan 97000, Mexico
3 University Chair at Comecyt, Mexican Council of Science and Technology, Autonomous University of the State of Mexico UAEM 56900, Amecameca de Juárez, State of Mexico, Mexico
4 Autonomous University of the State of Mexico UAEM 56900, Amecameca de Juárez, State of Mexico, Mexico


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Creative Commons License
© 2023 Núñez et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondonce to this author at the University chair at Comecyt, Mexican Council of Science and Technology Autonomous University of the State of Mexico UAEM 56900, Amecameca de Juárez, State of Mexico, Mexico; E-mail: ariadnafloresortega@gmail.com


Abstract

Background:

Topically applied antiparasitic drugs used in dogs have evolved in terms of active ingredients, but progress has also been made through the development of drugs that control both ectoparasites and enteroparasites (nematodes and cestodes).

Objective:

The aim of this study is to evaluate the effectiveness of Moxidectin 3.5g/ Praziquantel 10.0g and Imidacloprid 10.0g/ Moxidectin 3.5g/ Praziquantel 10.0g combinations applied topically in dogs with helminths (cestodes and nematodes) and ectoparasites, respectively.

Methods:

A total number of 276 dogs were analyzed. Dogs with nematodes or cestodes were treated with Moxidectin 3.5g/ Praziquantel 10.0g. All the positive cases for ectoparasites were treated with Imidacloprid 10.0g/ Moxidectin 3.5g/ Praziquantel 10.0g.

Results:

The effectiveness of Moxidectin/ Praziquantel was ≥99.8% from day 14 to day 35 on all the nematodes analyzed. The effectiveness of Moxidectin 3.5g/ Praziquantel 10.0g for Dipylidium caninum was significant on day 7 (75%) and reached 100% by day 14. A significant efficacy for Taenia spp. was achieved by day 7 and 100% from day 28 AT. Eighty-three dogs tested positive for 11 classes of ectoparasites. The Imidacloprid 10.0g /Moxidectin 3.5g/ Praziquantel 10.0g treatment proved to be effective in all the ectoparasites from day 7, until reaching 100% effectiveness by day 14 in the Linognathus setosus, Ctenocephalides canis, Amblyomma americanum, Ixodes spp., Rhipicephalus sanguineus, and Dermacentor reticulatus sp. We found a positive correlation (r= 0.7430, p= <0.0001) between the pruritus scale and lesion scale.

Conclusión:

The use of Moxidectin 3.5g /Praziquantel 10.0g applied topically was effective against nematodes and cestodes. Imidacloprid 10.0g/ Moxidectin 3.5g/ Praziquantel 10.0g was effective against ectoparasites and pruritus.

Keywords: Canine, Ectoparasites, Endoparasites, Pruritus, Spot on , Drugs.